CDB15:0000983 LAMA1 — RPSA

Experimentally validated in Human; Orthology-inferred in Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset

Title

Journal:; Year Published:

Abstract

The human laminin receptor is a member of the integrin family of cell adhesion receptors.

Science, 1988; PubMed, Homo sapiens LAMA1 — Homo sapiens RPSA

ABSTRACT: A receptor for the adhesive basement membrane protein, laminin, was isolated from human glioblastoma cells by affinity chromatography on laminin. This receptor has a heterodimeric structure similar to that of receptors for other extracellular matrix proteins such as fibronectin and vitronectin. Incorporation of the laminin receptor into liposomal membranes makes it possible for liposomes to attach to surfaces coated with laminin. The receptor liposomes also attached to some extent to surfaces coated with fibronectin, but not with other matrix proteins. These properties identify the laminin receptor as a member of the integrin family of cell adhesion receptors.

Basic Information on LAMA1

Ligand Name: laminin subunit alpha 1

Other Symbols: LAMA

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: LAMA1

GeneCards: LAMA1

HGNC Gene Group: Laminin subunits

Functional Annotations for LAMA1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for LAMA1

LAMA1 — ITGA1 ・ LAMA1 — ITGA2 ・ LAMA1 — ITGA6 ・ LAMA1 — ITGA7 ・ LAMA1 — ITGB1 ・ LAMA1 — ITGB4 ・ LAMA1 — ITGB8 ・ LAMA1 — DAG1

Basic Information on RPSA

Receptor Name: ribosomal protein SA

Other Symbols: LAMR1, LRP, 37LRP, p40, SA, uS2

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: RPSA

GeneCards: RPSA

HGNC Gene Group: Ribosomal proteins, Small nucleolar RNA host genes

Functional Annotations for RPSA

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for RPSA

LAMA2 — RPSA ・ LAMB2 — RPSA ・ PRND — RPSA ・ APP — RPSA