CDB15:0000977 LAMA1 — ITGA2

Experimentally validated in Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan.

FEBS letters, 1998; PubMed, Mus Musculus Lama1 — Homo sapiens ITGA2

ABSTRACT: The N-terminal domains VI plus V (62 kDa) and V alone (43 kDa) of the laminin alpha1 chain were obtained as recombinant products and shown to be folded into a native form by electron microscopy and immunological assays. Domain VI alone, which corresponds to an LN module, did not represent an autonomously folding unit in mammalian cells, however. Fragment alpha1VI/V, but not fragment alpha1V, bound to purified alpha1beta1 and alpha2beta1 integrins, to heparin, and to heparan sulfate-substituted domains I and V of perlecan. This localized the binding activities to the LN module, which contains two basic sequences suitable for heparin interactions.

Basic Information on LAMA1

Ligand Name: laminin subunit alpha 1

Other Symbols: LAMA

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: LAMA1

GeneCards: LAMA1

HGNC Gene Group: Laminin subunits

Functional Annotations for LAMA1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for LAMA1

LAMA1 — ITGA1 ・ LAMA1 — ITGA6 ・ LAMA1 — ITGA7 ・ LAMA1 — ITGB1 ・ LAMA1 — ITGB4 ・ LAMA1 — ITGB8 ・ LAMA1 — RPSA ・ LAMA1 — DAG1

Basic Information on ITGA2

Receptor Name: integrin subunit alpha 2

Other Symbols: CD49B, GPIa, VLAA2, HPA-5

Receptor Location: cell membrane based on perplexity

HGNC Gene Symbol Report: ITGA2

GeneCards: ITGA2

HGNC Gene Group: CD molecules, Integrins

Functional Annotations for ITGA2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ITGA2

CHAD — ITGA2 ・ COL11A1 — ITGA2 ・ COL1A1 — ITGA2 ・ COL1A2 — ITGA2 ・ COL2A1 — ITGA2 ・ COL3A1 — ITGA2 ・ COL4A1 — ITGA2 ・ COL4A3 — ITGA2 ・ COL4A4 — ITGA2 ・ COL4A5 — ITGA2 ・ COL4A6 — ITGA2 ・ COL8A1 — ITGA2 ・ FN1 — ITGA2 ・ HSPG2 — ITGA2 ・ LAMA2 — ITGA2 ・ MMP1 — ITGA2 ・ TNC — ITGA2 ・ CDH1 — ITGA2 ・ COL11A2 — ITGA2 ・ COL4A2 — ITGA2 ・ COL5A1 — ITGA2