CDB15:0000913 IL4 — IL2RG

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor.

Science, 1993; PubMed, Homo sapiens IL4 — Homo sapiens IL2RG

ABSTRACT: The interleukin-2 (IL-2) receptor gamma chain (IL-2R gamma) is an essential component of high- and intermediate-affinity IL-2 receptors. IL-2R gamma was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data, the ability of IL-2R gamma to augment IL-4 binding affinity, and the requirement for IL-2R gamma in IL-4-mediated phosphorylation of insulin receptor substrate-1. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.

Basic Information on IL4

Ligand Name: interleukin 4

Other Symbols: BSF1, IL-4, BCGF1, BCGF-1, MGC79402

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: IL4

GeneCards: IL4

HGNC Gene Group: Receptor ligands: Interleukins

Functional Annotations for IL4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for IL4

IL4 — IL13RA1 ・ IL4 — IL13RA2 ・ IL4 — IL4R ・ IL4 — IL2RB

Basic Information on IL2RG

Receptor Name: interleukin 2 receptor subunit gamma

Other Symbols: SCIDX1, IMD4, CIDX, CD132

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: IL2RG

GeneCards: IL2RG

HGNC Gene Group: CD molecules, Fibronectin type III domain containing, Interleukin receptors

Functional Annotations for IL2RG

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for IL2RG

IL13 — IL2RG ・ IL15 — IL2RG ・ IL21 — IL2RG ・ IL2 — IL2RG ・ IL7 — IL2RG ・ IL9 — IL2RG