CDB15:0000891 IL21 — IL2RG

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex.

Journal of immunology, 2001; PubMed, Homo sapiens IL21 — Homo sapiens IL2RG

ABSTRACT: The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for IL-4, IL-7, IL-9, and IL-15 as well as IL-2. Here we show that the gamma(c) is also shared with the IL-21R complex. Although IL-21 binds to the IL-21R expressed on gamma(c)-deficient ED40515(-) cells, IL-21 is unable to transduce any intracytoplasmic signals. However, in EDgamma-16 cells, a gamma(c)-transfected ED40515(-) cell line, IL-21 binds to the IL-21R and can activate Janus kinase (JAK)1, JAK3, STAT1, and STAT3. The chemical cross-linking study reveals the direct binding of IL-21 to the gamma(c). These data clearly demonstrate that the gamma(c) is an indispensable subunit of the functional IL-21R complex.

Basic Information on IL21

Ligand Name: interleukin 21

Other Symbols: Za11, IL-21

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: IL21

GeneCards: IL21

HGNC Gene Group: Receptor ligands: Interleukins

Functional Annotations for IL21

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for IL21

IL21 — IL21R

Basic Information on IL2RG

Receptor Name: interleukin 2 receptor subunit gamma

Other Symbols: SCIDX1, IMD4, CIDX, CD132

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: IL2RG

GeneCards: IL2RG

HGNC Gene Group: CD molecules, Fibronectin type III domain containing, Interleukin receptors

Functional Annotations for IL2RG

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for IL2RG

IL13 — IL2RG ・ IL15 — IL2RG ・ IL2 — IL2RG ・ IL4 — IL2RG ・ IL7 — IL2RG ・ IL9 — IL2RG