CDB15:0000733 GZMB — IGF2R

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.

Cell, 2000; PubMed, Homo sapiens GZMB — Homo sapiens IGF2R

ABSTRACT: The serine proteinase granzyme B is crucial for the rapid induction of target cell apoptosis by cytotoxic T cells. Granzyme B was recently demonstrated to enter cells in a perforin-independent manner, thus predicting the existence of a cell surface receptor(s). We now present evidence that this receptor is the cation-independent mannose 6-phosphate/insulin-like growth factor receptor (CI-MPR). Inhibition of the granzyme B-CI-MPR interaction prevented granzyme B cell surface binding, uptake, and the induction of apoptosis. Significantly, expression of the CI-MPR was essential for cytotoxic T cell-mediated apoptosis of target cells in vitro and for the rejection of allogeneic cells in vivo. These results suggest a novel target for immunotherapy and a potential mechanism used by tumors for immune evasion.

Basic Information on GZMB

Ligand Name: granzyme B

Other Symbols: CTLA1, CSPB, CCPI, CGL-1, CSP-B, CGL1, CTSGL1, HLP, SECT

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: GZMB

GeneCards: GZMB

HGNC Gene Group: Granule associated serine proteases of immune defence

Functional Annotations for GZMB

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for GZMB

GZMB — CHRM3

Basic Information on IGF2R

Receptor Name: insulin like growth factor 2 receptor

Other Symbols: CD222, MPRI, MPR1, CIMPR, M6P-R, CI-M6PR, CI-MPR, MPR300

Receptor Location: cell membrane based on perplexity

HGNC Gene Symbol Report: IGF2R

GeneCards: IGF2R

HGNC Gene Group: MRH domain containing, CD molecules

Functional Annotations for IGF2R

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for IGF2R

IGF2 — IGF2R ・ CCN2 — IGF2R ・ PLAUR — IGF2R ・ PLG — IGF2R