CDB15:0000671 FN1 — TSHR

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

TSH receptor interaction with the extracellular matrix: role on constitutive activity and sensitivity to hormonal stimulation.

Molecular endocrinology, 2002; PubMed, Homo sapiens FN1 — Homo sapiens TSHR

ABSTRACT: Using immunocytochemistry, we have observed that the TSH receptor (TSHR) is concentrated at the leading edge of lamellipodia in both cultured human thyroid cells and in various transfected cells. This segregation of the receptor is due to its interaction with extracellular matrix (ECM) and specially with fibronectin. The TSHR, which interacts with the ECM, is known to undergo cleavage by a matrix metalloprotease. The homologous LH receptor, which does not interact with ECM, is not cleaved. The attachment to the ECM modifies the functional properties of the receptor: it increases adenylate cyclase stimulation by hormone, whereas PLC stimulation is not modified. Furthermore, the constitutive activity of the TSHR is only observed in attached cells, suggesting that it is dependent on TSHR interaction with the ECM. Thus, aside from its classical properties of hormone binding and signalization through G proteins, the TSHR is also involved in cell-matrix interactions, which modulate its functional properties.

Basic Information on FN1

Ligand Name: fibronectin 1

Other Symbols: MSF, CIG, LETS, GFND2, FINC, lnc-ABCA12-8

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: FN1

GeneCards: FN1

HGNC Gene Group: Receptor ligands, Fibronectin type III domain containing

Functional Annotations for FN1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for FN1

FN1 — CD44 ・ FN1 — COL13A1 ・ FN1 — ITGA2 ・ FN1 — ITGA2B ・ FN1 — ITGA3 ・ FN1 — ITGA4 ・ FN1 — ITGA5 ・ FN1 — ITGA8 ・ FN1 — ITGA9 ・ FN1 — ITGAV ・ FN1 — ITGB1 ・ FN1 — ITGB3 ・ FN1 — ITGB6 ・ FN1 — ITGB7 ・ FN1 — ITGB8 ・ FN1 — MAG ・ FN1 — SDC2 ・ FN1 — CD248 ・ FN1 — DPP4 ・ FN1 — FLRT2 ・ FN1 — SDC4

Basic Information on TSHR

Receptor Name: thyroid stimulating hormone receptor

Other Symbols: LGR3

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: TSHR

GeneCards: TSHR

HGNC Gene Group: 7TM proteins

Functional Annotations for TSHR

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for TSHR

CGA — TSHR ・ GPHA2 — TSHR ・ TSHB — TSHR ・ GPHB5 — TSHR