CDB15:0000669 FN1 — MAG

Experimentally validated in Mixed species, Mouse; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Fibronectin is a binding partner for the myelin-associated glycoprotein (siglec-4a).

FEBS letters, 2001; PubMed, Mus Musculus Fn1 — Mus Musculus Mag
ABSTRACT: The myelin-associated glycoprotein (MAG) mediates cell-cell interactions between myelinating glial cells and neurons. Here we describe the extracellular matrix glycoprotein fibronectin as a binding partner of MAG. It has been identified by affinity precipitation with MAG-Fc from NG108-15 cells and by microsequencing of two peptides derived from a 210-kDa protein band. Western blot analysis showed that fibronectin is also present in MAG binding partners isolated from N(2)A (murine neuroblastoma) cells, rat brain and rat spinal cord. Different fibronectin isoforms have been isolated from brains of young and adult rats, indicating that the expression of MAG binding fibronectin changes during development.
Basic Information on FN1
Ligand Name: fibronectin 1
Other Symbols: MSF, CIG, LETS, GFND2, FINC, lnc-ABCA12-8
Ligand Location: secreted based on perplexity, uniprot
HGNC Gene Symbol Report: FN1
GeneCards: FN1
Functional Annotations for FN1
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for FN1
FN1 — CD44 ・ FN1 — COL13A1 ・ FN1 — ITGA2 ・ FN1 — ITGA2B ・ FN1 — ITGA3 ・ FN1 — ITGA4 ・ FN1 — ITGA5 ・ FN1 — ITGA8 ・ FN1 — ITGA9 ・ FN1 — ITGAV ・ FN1 — ITGB1 ・ FN1 — ITGB3 ・ FN1 — ITGB6 ・ FN1 — ITGB7 ・ FN1 — ITGB8 ・ FN1 — SDC2 ・ FN1 — TSHR ・ FN1 — CD248 ・ FN1 — DPP4 ・ FN1 — FLRT2 ・ FN1 — SDC4
Basic Information on MAG
Receptor Name: myelin associated glycoprotein
Other Symbols: GMA, SIGLEC4A, SIGLEC-4A, S-MAG, SIGLEC4
Receptor Location: cell membrane based on perplexity, uniprot
HGNC Gene Symbol Report: MAG
GeneCards: MAG
Functional Annotations for MAG
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for MAG
← CDB15 FN1 ITGB8
CDB15 FN1 SDC2 →