CDB25:0003629 FGF21 — KLB

Experimentally validated in Mixed species, Mouse; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.

PloS one, 2012; PubMed, Homo sapiens FGF21 — Mus Musculus Klb
ABSTRACT: Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21 redirect FGFR signaling to regulation of metabolic homeostasis and suppression of obesity and diabetes. However, the identity of the predominant metabolic tissue in which a major FGFR-KLB resides that critically mediates the differential actions and metabolism effects of FGF19 and FGF21 remain unclear.
Basic Information on FGF21
Ligand Name: fibroblast growth factor 21
Other Symbols: N/A
Ligand Location: secreted based on perplexity, uniprot
HGNC Gene Symbol Report: FGF21
GeneCards: FGF21
Functional Annotations for FGF21
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for FGF21
FGF21 — FGFR2 ・ FGF21 — FGFR4 ・ FGF21 — FGFR1 ・ FGF21 — FGFR3
Basic Information on KLB
Receptor Name: klotho beta
Other Symbols: N/A
Receptor Location: cell membrane based on perplexity, uniprot
HGNC Gene Symbol Report: KLB
GeneCards: KLB
Functional Annotations for KLB
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for KLB
FGF19 — KLB
← CDB25 FGF21 FGFR3
CDB25 FGFBP1 NRP1 →