CDB15:0000592 FGF19 — KLB

Experimentally validated in Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.

PloS one, 2012; PubMed, Homo sapiens FGF19 — Mus Musculus Klb
ABSTRACT: Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21 redirect FGFR signaling to regulation of metabolic homeostasis and suppression of obesity and diabetes. However, the identity of the predominant metabolic tissue in which a major FGFR-KLB resides that critically mediates the differential actions and metabolism effects of FGF19 and FGF21 remain unclear.
Basic Information on FGF19
Ligand Name: fibroblast growth factor 19
Other Symbols: N/A
Ligand Location: secreted based on perplexity, uniprot
HGNC Gene Symbol Report: FGF19
GeneCards: FGF19
Functional Annotations for FGF19
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for FGF19
FGF19 — FGFR1 ・ FGF19 — FGFR2 ・ FGF19 — FGFR3 ・ FGF19 — FGFR4
Basic Information on KLB
Receptor Name: klotho beta
Other Symbols: N/A
Receptor Location: cell membrane based on perplexity, uniprot
HGNC Gene Symbol Report: KLB
GeneCards: KLB
Functional Annotations for KLB
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for KLB
FGF21 — KLB
← CDB15 FGF19 FGFR4
CDB15 FGF1 CD44 →