CDB20:0002740 FAM3D — FPR2

Experimentally validated in Human, Mouse; Orthology-inferred in Human, Rat, Frog, Chicken, Macaque, Dog, Chimp, Horse, Marmoset, Mouse, Zebrafish

Title

Journal:; Year Published:

Abstract

Deficiency of FAM3D (Family With Sequence Similarity 3, Member D), A Novel Chemokine, Attenuates Neutrophil Recruitment and Ameliorates Abdominal Aortic Aneurysm Development.

Arteriosclerosis, thrombosis, and vascular biology, 2018; PubMed, Homo sapiens FAM3D — Homo sapiens FPR2

ABSTRACT: Chemokine-mediated neutrophil recruitment contributes to the pathogenesis of abdominal aortic aneurysm (AAA) and may serve as a promising therapeutic target. FAM3D (family with sequence similarity 3, member D) is a recently identified novel chemokine. Here, we aimed to explore the role of FAM3D in neutrophil recruitment and AAA development.

Basic Information on FAM3D

Ligand Name: FAM3 metabolism regulating signaling molecule D

Other Symbols: EF7, OIT1

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: FAM3D

GeneCards: FAM3D

HGNC Gene Group: unknown

Functional Annotations for FAM3D

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for FAM3D

FAM3D — FPR1

Basic Information on FPR2

Receptor Name: formyl peptide receptor 2

Other Symbols: FPRL1, LXA4R, HM63, FPRH2, FMLPX, FPR2A, FMLP-R-II, ALXR, ALX

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: FPR2

GeneCards: FPR2

HGNC Gene Group: 7TM proteins

Functional Annotations for FPR2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for FPR2

ANXA1 — FPR2 ・ APP — FPR2 ・ CAMP — FPR2 ・ SAA1 — FPR2 ・ PLAUR — FPR2 ・ TAFA5 — FPR2