CDB20:0002739 FAM3D — FPR1

Experimentally validated in Human, Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Chimp, Horse, Marmoset, Mouse

Title

Journal:; Year Published:

Abstract

Deficiency of FAM3D (Family With Sequence Similarity 3, Member D), A Novel Chemokine, Attenuates Neutrophil Recruitment and Ameliorates Abdominal Aortic Aneurysm Development.

Arteriosclerosis, thrombosis, and vascular biology, 2018; PubMed, Homo sapiens FAM3D — Homo sapiens FPR1

ABSTRACT: Chemokine-mediated neutrophil recruitment contributes to the pathogenesis of abdominal aortic aneurysm (AAA) and may serve as a promising therapeutic target. FAM3D (family with sequence similarity 3, member D) is a recently identified novel chemokine. Here, we aimed to explore the role of FAM3D in neutrophil recruitment and AAA development.

Basic Information on FAM3D

Ligand Name: FAM3 metabolism regulating signaling molecule D

Other Symbols: EF7, OIT1

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: FAM3D

GeneCards: FAM3D

HGNC Gene Group: unknown

Functional Annotations for FAM3D

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for FAM3D

FAM3D — FPR2

Basic Information on FPR1

Receptor Name: formyl peptide receptor 1

Other Symbols: FPR, FMLP

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: FPR1

GeneCards: FPR1

HGNC Gene Group: 7TM proteins

Functional Annotations for FPR1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for FPR1

ANXA1 — FPR1 ・ TAFA4 — FPR1 ・ CTSG — FPR1