CDB20:0002626 CCL4L1 — CCR3

Experimentally validated in Human; Orthology-inferred in Zebrafish

Title

Journal:; Year Published:

Abstract

Functional redundancy of the human CCL4 and CCL4L1 chemokine genes.

Biochemical and biophysical research communications, 2004; PubMed, Homo sapiens CCL4L1 — Homo sapiens CCR3

ABSTRACT: CCL4 and CCL4L1 are two CC chemokine genes located at chromosome 17q21 whose mature proteins differ at only a single amino acid. Abundant functional information exists for CCL4, however, CCL4L1 has only recently been recognized as a distinct gene, thus information describing it is wanting. The CCL4L1 protein was synthesized in Escherichia coli and compared with the CCL4 protein. Competitive binding studies using HEK-293/CCR5 cells produced comparable EC50 values for the two proteins. Similarly, chemotaxis assays with cells expressing CCR1, CCR3, or CCR5 revealed no substantial differences. CCL4L1 was somewhat more effective at inhibiting HIV-1 replication in PBMCs than was CCL4, however the difference was not statistically significant. These data combined with the observation of individual variation in CCL4L1 gene copy number [Eur. J. Immunol. 32 (2002) 3016, Genomics 83 (2004) 735] support the contention that the CCL4 and CCL4L1 proteins have redundant functions.

Basic Information on CCL4L1

Ligand Name: C-C motif chemokine ligand 4 like 1

Other Symbols: N/A

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: CCL4L1

GeneCards: CCL4L1

HGNC Gene Group: Receptor ligands: Chemokine ligands

Functional Annotations for CCL4L1

Gene Ontologies: ,

Expression Profile: , Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, AI summary (LLM)

Interactions with other Receptors for CCL4L1

CCL4L1 — CCR1 ・ CCL4L1 — CCR5

Basic Information on CCR3

Receptor Name: C-C motif chemokine receptor 3

Other Symbols: CMKBR3, CC-CKR-3, CKR3, CD193

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: CCR3

GeneCards: CCR3

HGNC Gene Group: 7TM proteins, CD molecules

Functional Annotations for CCR3

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CCR3

CCL11 — CCR3 ・ CCL13 — CCR3 ・ CCL14 — CCR3 ・ CCL15 — CCR3 ・ CCL24 — CCR3 ・ CCL26 — CCR3 ・ CCL28 — CCR3 ・ CCL2 — CCR3 ・ CCL3L1 — CCR3 ・ CCL3 — CCR3 ・ CCL4 — CCR3 ・ CCL5 — CCR3 ・ CCL7 — CCR3 ・ CCL8 — CCR3 ・ CXCL10 — CCR3 ・ CXCL11 — CCR3 ・ CXCL9 — CCR3 ・ CCL18 — CCR3