CDB25:0003213 C1QTNF5 — ADIPOR1

Experimentally validated in Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

C1q/TNF-related proteins, a family of novel adipokines, induce vascular relaxation through the adiponectin receptor-1/AMPK/eNOS/nitric oxide signaling pathway.

Arteriosclerosis, thrombosis, and vascular biology, 2011; PubMed, Mus Musculus C1qtnf5 — Homo sapiens ADIPOR1

ABSTRACT: Reduced plasma adiponectin (APN) in diabetic patients is associated with endothelial dysfunction. However, APN knockout animals manifest modest systemic dysfunction unless metabolically challenged. The protein family CTRPs (C1q/TNF-related proteins) has recently been identified as APN paralogs and some CTRP members share APN's metabolic regulatory function. However, the vasoactive properties of CTRPs remain completely unknown.

Basic Information on C1QTNF5

Ligand Name: C1q and TNF related 5

Other Symbols: CTRP5, DKFZp586B0621, LORD

Ligand Location: secreted based on perplexity, uniprot, cell membrane based on perplexity

HGNC Gene Symbol Report: C1QTNF5

GeneCards: C1QTNF5

HGNC Gene Group: C1q domain containing

Functional Annotations for C1QTNF5

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for C1QTNF5

C1QTNF5 — MFRP

Basic Information on ADIPOR1

Receptor Name: adiponectin receptor 1

Other Symbols: PAQR1, ACDCR1

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: ADIPOR1

GeneCards: ADIPOR1

HGNC Gene Group: Adiponectin receptors, Progestin and adipoQ receptor family

Functional Annotations for ADIPOR1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ADIPOR1

ADIPOQ — ADIPOR1 ・ C1QTNF3 — ADIPOR1 ・ C1QTNF9 — ADIPOR1