CDB25:0004557 H60b — Klrk1

Experimentally validated in Mouse; Orthology-inferred in Rat

Title

Journal:; Year Published:

Abstract

Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.

Immunity, 2000; PubMed, Mus Musculus H60b — Mus Musculus Klrk1

ABSTRACT: Here we describe a family of GPI-anchored cell surface proteins that function as ligands for the mouse activating NKG2D receptor. These molecules are encoded by the retinoic acid early inducible (RAE-1) and H60 minor histocompatibility antigen genes on mouse chromosome 10 and show weak homology with MHC class I. Expression of the NKG2D ligands is low or absent on normal, adult tissues; however, they are constitutively expressed on some tumors and upregulated by retinoic acid. Ectopic expression of RAE-1 and H60 confers target susceptibility to NK cell attack. These studies identify a family of ligands for the activating NKG2D receptor on NK and T cells, which may play an important role in innate and adaptive immunity.

Basic Information on H60b

Ligand Name: histocompatibility 60b

Other Symbols: EG667281

Ligand Location: cell membrane based on perplexity, uniprot

Ensembl Gene Symbol Report: H60b (not in the official report)

MGI: H60b

NCBI: H60b

Functional Annotations for H60b

Gene Ontologies: Mouse Genome Informatics, quickGO

Expression Profile: Expression Atlas (RNA) (no ensemble gene id), GEO (RNA and protein), Allen Brain Atlas (RNA), Mouse Cell Atlas 1.1 (RNA)

Disease Annotations: MalaCards (Mouse-specific), AI summary (LLM)

Interactions with other Receptors for H60b

Basic Information on Klrk1

Receptor Name: killer cell lectin-like receptor subfamily K, member 1

Other Symbols: NKG2-D, Nkg2d, D6H12S2489E

Receptor Location: cell membrane based on perplexity, uniprot

Ensembl Gene Symbol Report: Klrk1 (not in the official report)

MGI: Klrk1

NCBI: Klrk1

Functional Annotations for Klrk1

Gene Ontologies: Mouse Genome Informatics, quickGO

Expression Profile: Expression Atlas (RNA) (no ensemble gene id), GEO (RNA and protein), Allen Brain Atlas (RNA), Mouse Cell Atlas 1.1 (RNA)

Disease Annotations: MalaCards (Mouse-specific), AI summary (LLM)

Interactions with other Ligands for Klrk1

H60a — Klrk1 ・ H60c — Klrk1