CDB25:0004554 Defb2 — Tlr4

Experimentally validated in Mouse; Orthology-inferred in none

Title

Journal:; Year Published:

Abstract

Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2.

Science, 2002; PubMed, Mus Musculus Defb2 — Mus Musculus Tlr4

ABSTRACT: beta-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. We demonstrate that murine beta-defensin 2 (mDF2beta) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and dendritic cell maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2beta may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens.

Basic Information on Defb2

Ligand Name: defensin beta 2

Other Symbols: N/A

Ligand Location: secreted based on uniprot

Ensembl Gene Symbol Report: Defb2 (not in the official report)

MGI: Defb2

NCBI: Defb2

Functional Annotations for Defb2

Gene Ontologies: Mouse Genome Informatics, quickGO

Expression Profile: Expression Atlas (RNA) (no ensemble gene id), GEO (RNA and protein), Allen Brain Atlas (RNA), Mouse Cell Atlas 1.1 (RNA)

Disease Annotations: MalaCards (Mouse-specific), AI summary (LLM)

Interactions with other Receptors for Defb2

Defb2 — Ccr6

Basic Information on Tlr4

Receptor Name: toll-like receptor 4

Other Symbols: Lps, Rasl2-8, lipopolysaccharide response

Receptor Location: cell membrane based on perplexity, uniprot

Ensembl Gene Symbol Report: Tlr4 (not in the official report)

MGI: Tlr4

NCBI: Tlr4

Functional Annotations for Tlr4

Gene Ontologies: Mouse Genome Informatics, quickGO

Expression Profile: Expression Atlas (RNA) (no ensemble gene id), GEO (RNA and protein), Allen Brain Atlas (RNA), Mouse Cell Atlas 1.1 (RNA)

Disease Annotations: MalaCards (Mouse-specific), AI summary (LLM)

Interactions with other Ligands for Tlr4

Fcna — Tlr4 ・ Saa3 — Tlr4