CDB15:0001557 VTN — ITGA2B

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Vitronectin binds to activated human platelets and plays a role in platelet aggregation.

The Journal of clinical investigation, 1990; PubMed, Homo sapiens VTN — Homo sapiens ITGA2B

ABSTRACT: Vitronectin (Vn) is a multifunctional 75-kD glycoprotein that is present in plasma and the extracellular matrix. Vn functions as a complement regulatory protein in plasma, and promotes the growth and attachment of cells in tissue culture. Recent cDNA cloning reveals that like other adhesive proteins, Vn contains the sequence Arg-Gly-Asp and binds to some members of the integrin class of adhesive membrane receptors. In liposomes, the platelet membrane glycoprotein complex IIb/IIIa binds Vn, as well as fibrinogen, von Willebrand factor, and fibronectin. We examined the binding of purified Vn to resting and stimulated human platelets. Vn bound to thrombin-stimulated platelets in a calcium-dependent, specific, and saturable manner with a Kd of 320 nM and 8,000 sites per platelet. Epinephrine or ADP stimulation led to specific binding with KdS of 93 and 116 nM, respectively. Binding was inhibited by the tetrapeptide Arg-Gly-Asp-Ser and by monoclonal and polyclonal antibodies to GPIIb/IIIa. Endogenous platelet Vn stores were identified in immunoblots of gel-filtered platelets and the surface expression of endogenous platelet Vn was thrombin inducible. Monoclonal as well as polyclonal antibodies to Vn inhibited platelet aggregation, suggesting that Vn plays a role in the formation of stable platelet aggregates.

Basic Information on VTN

Ligand Name: vitronectin

Other Symbols: VN

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: VTN

GeneCards: VTN

HGNC Gene Group: Complement system, Receptor ligands

Functional Annotations for VTN

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for VTN

VTN — ITGA5 ・ VTN — ITGA8 ・ VTN — ITGAV ・ VTN — ITGB1 ・ VTN — ITGB3 ・ VTN — ITGB5 ・ VTN — ITGB6 ・ VTN — ITGB8 ・ VTN — PLAUR ・ VTN — PVR ・ VTN — C1QBP

Basic Information on ITGA2B

Receptor Name: integrin subunit alpha 2b

Other Symbols: GP2B, CD41B, CD41, PPP1R93, GPIIb

Receptor Location: cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: ITGA2B

GeneCards: ITGA2B

HGNC Gene Group: CD molecules, Integrins, Protein phosphatase 1 regulatory subunits

Functional Annotations for ITGA2B

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ITGA2B

FGA — ITGA2B ・ FGB — ITGA2B ・ FGG — ITGA2B ・ FN1 — ITGA2B ・ ICAM4 — ITGA2B ・ THBS1 — ITGA2B ・ VWF — ITGA2B ・ CD40LG — ITGA2B ・ FBLN2 — ITGA2B ・ L1CAM — ITGA2B ・ RELN — ITGA2B