CDB20:0002956 TNFSF12 — CD163

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

The CD163-expressing macrophages recognize and internalize TWEAK: potential consequences in atherosclerosis.

Atherosclerosis, 2009; PubMed, Homo sapiens TNFSF12 — Homo sapiens CD163

ABSTRACT: CD163 is a new potential scavenger receptor of Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) which elicits diverse biologic actions involved in atherosclerosis. We have analyzed the importance of TWEAK-CD163 interaction in atherosclerosis.

Basic Information on TNFSF12

Ligand Name: TNF superfamily member 12

Other Symbols: TWEAK, DR3LG, APO3L, TNF12

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: TNFSF12

GeneCards: TNFSF12

HGNC Gene Group: Receptor ligands: Tumor necrosis factor superfamily

Functional Annotations for TNFSF12

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for TNFSF12

TNFSF12 — TNFRSF12A

Basic Information on CD163

Receptor Name: CD163 molecule

Other Symbols: M130, MM130, SCARI1

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: CD163

GeneCards: CD163

HGNC Gene Group: Scavenger receptors, Scavenger receptor cysteine rich domain containing, CD molecules

Functional Annotations for CD163

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CD163

HP — CD163 ・ ADAMTS13 — CD163