CDB15:0001495 TNFSF10 — TNFRSF10D

Experimentally validated in Human; Orthology-inferred in Frog, Zebrafish, Chicken, Macaque, Pig, Cow, Chimp, Horse, Sheep

Title

Journal:; Year Published:

Abstract

The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain.

Immunity, 1997; PubMed, Homo sapiens TNFSF10 — Homo sapiens TNFRSF10D

ABSTRACT: A fourth member of the emerging TRAIL receptor family, TRAIL-R4, has been cloned and characterized. TRAIL-R4 encodes a 386-amino acid protein with an extracellular domain showing 58%-70% identity to those of TRAIL-R1, TRAIL-R2, and TRAIL-R3. The signaling capacity of TRAIL-R4 is similar to that of TRAIL-R1 and TRAIL-R2 with respect to NF-kappaB activation, but differs in its inability to induce apoptosis. Yet TRAIL-R4 retains a C-terminal element containing one third of a consensus death domain motif. Transient overexpression of TRAIL-R4 in cells normally sensitive to TRAIL-mediated killing confers complete protection, suggesting that one function of TRAIL-R4 may be inhibition of TRAIL cytotoxicity. Like TRAIL-R1 and TRAIL-R2, this receptor shows widespread tissue expression. The human TRAIL-R4 gene has been mapped to chromosome 8p22-21, clustered with three other TRAIL receptors.

Basic Information on TNFSF10

Ligand Name: TNF superfamily member 10

Other Symbols: TRAIL, Apo-2L, TL2, CD253, TANCR

Ligand Location: secreted based on perplexity, uniprot, cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: TNFSF10

GeneCards: TNFSF10

HGNC Gene Group: CD molecules, Receptor ligands: Tumor necrosis factor superfamily

Functional Annotations for TNFSF10

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for TNFSF10

TNFSF10 — TNFRSF10A ・ TNFSF10 — TNFRSF10B ・ TNFSF10 — TNFRSF10C

Basic Information on TNFRSF10D

Receptor Name: TNF receptor superfamily member 10d

Other Symbols: DcR2, TRUNDD, TRAILR4, CD264

Receptor Location: cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: TNFRSF10D

GeneCards: TNFRSF10D

HGNC Gene Group: CD molecules, Tumor necrosis factor receptor superfamily

Functional Annotations for TNFRSF10D

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for TNFRSF10D