CDB25:0004348 TAFA5 — S1PR2

Experimentally validated in Human, Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2.

Circulation, 2018; PubMed, Homo sapiens TAFA5 — Homo sapiens S1PR2

ABSTRACT: Obesity plays crucial roles in the development of cardiovascular diseases. However, the mechanisms that link obesity and cardiovascular diseases remain elusive. Compelling evidence indicates that adipokines play an important role in obesity-related cardiovascular diseases. Here, we found a new adipokine-named family with sequence similarity 19, member A5 (FAM19A5), a protein with unknown function that was predicted to be distantly related to the CC-chemokine family. We aimed to test whether adipose-derived FAM19A5 regulates vascular pathology on injury.

Basic Information on TAFA5

Ligand Name: TAFA chemokine like family member 5

Other Symbols: FAM19A5, TAFA-5

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: TAFA5

GeneCards: TAFA5

HGNC Gene Group: TAFA chemokine like family

Functional Annotations for TAFA5

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for TAFA5

TAFA5 — FPR2 ・ TAFA5 — RNF167

Basic Information on S1PR2

Receptor Name: sphingosine-1-phosphate receptor 2

Other Symbols: EDG5, DFNB68, Gpcr13, H218, AGR16

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: S1PR2

GeneCards: S1PR2

HGNC Gene Group: 7TM proteins

Functional Annotations for S1PR2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for S1PR2

RTN4 — S1PR2