CDB20:0002936 SPON1 — LRP8

Experimentally validated in Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

F-spondin inhibits migration and differentiation of osteoclastic precursors.

Journal of periodontology, 2011; PubMed, Homo sapiens SPON1 — Mus Musculus Lrp8

ABSTRACT: Clinically, severe cemental resorption is a rare consequence of periodontitis, although alveolar bone resorption by osteoclasts is one of the main pathologic changes. F-spondin is a secreted neuronal glycoprotein that localizes to the cementum. F-spondin is among the cementum-specific factors in periodontal tissue that have been reported. However, the effects of F-spondin on osteoclastogenesis have not yet been established. We examined the effects of F-spondin on stages of osteoclastogenesis, migration, and differentiation in a mouse osteoclastic precursor model, RAW 264 cells.

Basic Information on SPON1

Ligand Name: spondin 1

Other Symbols: KIAA0762, f-spondin

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: SPON1

GeneCards: SPON1

HGNC Gene Group: unknown

Functional Annotations for SPON1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for SPON1

SPON1 — APP

Basic Information on LRP8

Receptor Name: LDL receptor related protein 8

Other Symbols: APOER2, MCI1, LRP-8, HSZ75190

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: LRP8

GeneCards: LRP8

HGNC Gene Group: Low density lipoprotein receptors

Functional Annotations for LRP8

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for LRP8

APOE — LRP8 ・ RELN — LRP8 ・ CLU — LRP8 ・ SELENOP — LRP8