CDB25:0004284 SERPINF1 — PNPLA2

Experimentally validated in Human, Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL).

Journal of hepatology, 2008; PubMed, Homo sapiens SERPINF1 — Homo sapiens PNPLA2

ABSTRACT: Anti-angiogenic pigment epithelium-derived factor (PEDF) is a 50 kDa secreted glycoprotein that is highly expressed in hepatocytes. Adipose triglyceride lipase (ATGL), a novel lipase critical for triglyceride metabolism, is a receptor for PEDF. We postulated that hepatocyte triglyceride metabolism was dependent on interactions between PEDF and ATGL, and loss of PEDF would impair mobilization of triglycerides in the liver.

Basic Information on SERPINF1

Ligand Name: serpin family F member 1

Other Symbols: PEDF, EPC-1, PIG35

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: SERPINF1

GeneCards: SERPINF1

HGNC Gene Group: Serpin peptidase inhibitors

Functional Annotations for SERPINF1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for SERPINF1

SERPINF1 — PLXDC1 ・ SERPINF1 — PLXDC2

Basic Information on PNPLA2

Receptor Name: patatin like domain 2, triacylglycerol lipase

Other Symbols: desnutrin, TTS-2.2, ATGL, FP17548, iPLA2zeta

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: PNPLA2

GeneCards: PNPLA2

HGNC Gene Group: Lipases, Patatin like phospholipase domain containing

Functional Annotations for PNPLA2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for PNPLA2