CDB25:0004266 SEMA3G — PLXNA1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

A Novel SEMA3G Mutation in Two Siblings Affected by Syndromic GnRH Deficiency.

Neuroendocrinology, 2021; PubMed, Homo sapiens SEMA3G — Homo sapiens PLXNA1

ABSTRACT: Gonadotropin-releasing hormone (GnRH) deficiency causes hypogonadotropic hypogonadism (HH), a rare genetic disorder that impairs sexual reproduction. HH can be due to defective GnRH-secreting neuron development or function and may be associated with other clinical signs in overlapping genetic syndromes. With most of the cases being idiopathic, genetics underlying HH is still largely unknown.

Basic Information on SEMA3G

Ligand Name: semaphorin 3G

Other Symbols: FLJ00014, sem2

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: SEMA3G

GeneCards: SEMA3G

HGNC Gene Group: Immunoglobulin superfamily domain containing, Semaphorins

Functional Annotations for SEMA3G

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for SEMA3G

SEMA3G — NRP2 ・ SEMA3G — PLXNA4 ・ SEMA3G — PLXND1

Basic Information on PLXNA1

Receptor Name: plexin A1

Other Symbols: PLXN1, NOV

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: PLXNA1

GeneCards: PLXNA1

HGNC Gene Group: IPT domain containing, Plexins

Functional Annotations for PLXNA1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for PLXNA1

SEMA3A — PLXNA1 ・ SEMA3F — PLXNA1 ・ SEMA6D — PLXNA1 ・ SEMA5A — PLXNA1 ・ SEMA6C — PLXNA1 ・ SLIT1 — PLXNA1 ・ SLIT2 — PLXNA1 ・ SLIT3 — PLXNA1