CDB25:0004260 SEMA3C — PLXNB1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

SEMA3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1.

EMBO molecular medicine, 2018; PubMed, Homo sapiens SEMA3C — Homo sapiens PLXNB1

ABSTRACT: Growth factor receptor tyrosine kinase (RTK) pathway activation is a key mechanism for mediating cancer growth, survival, and treatment resistance. Cognate ligands play crucial roles in autocrine or paracrine stimulation of these RTK pathways. Here, we show SEMA3C drives activation of multiple RTKs including EGFR, ErbB2, and MET in a cognate ligand-independent manner via Plexin B1. SEMA3C expression levels increase in castration-resistant prostate cancer (CRPC), where it functions to promote cancer cell growth and resistance to androgen receptor pathway inhibition. SEMA3C inhibition delays CRPC and enzalutamide-resistant progression. Plexin B1 sema domain-containing:Fc fusion proteins suppress RTK signaling and cell growth and inhibit CRPC progression of LNCaP xenografts post-castration in vivo SEMA3C inhibition represents a novel therapeutic strategy for treatment of advanced prostate cancer.

Basic Information on SEMA3C

Ligand Name: semaphorin 3C

Other Symbols: SEMAE, SemE

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on hpa

HGNC Gene Symbol Report: SEMA3C

GeneCards: SEMA3C

HGNC Gene Group: Immunoglobulin superfamily domain containing, Semaphorins

Functional Annotations for SEMA3C

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for SEMA3C

SEMA3C — NRP1 ・ SEMA3C — NRP2 ・ SEMA3C — PLXND1 ・ SEMA3C — PLXNA4

Basic Information on PLXNB1

Receptor Name: plexin B1

Other Symbols: PLXN5, SEP, KIAA0407

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: PLXNB1

GeneCards: PLXNB1

HGNC Gene Group: IPT domain containing, Plexins

Functional Annotations for PLXNB1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for PLXNB1

SEMA4D — PLXNB1 ・ SEMA4A — PLXNB1