CDB15:0001320 RSPO3 — SDC4

Experimentally validated in Frog, Human; Orthology-inferred in Human, Mouse, Rat, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep, Frog

Title

Journal:; Year Published:

Abstract

Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis.

Developmental cell, 2011; PubMed, Homo sapiens RSPO3 — Homo sapiens SDC4

ABSTRACT: The R-Spondin (Rspo) family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. Despite growing biological importance, their mechanism of action is poorly understood. Here, we show that Rspo3 binds syndecan 4 (Sdc4) and that together they activate Wnt/PCP signaling. In Xenopus embryos, Sdc4 and Rspo3 are essential for two Wnt/PCP-driven processes-gastrulation movements and head cartilage morphogenesis. Rspo3/PCP signaling during gastrulation requires Wnt5a and is transduced via Fz7, Dvl, and JNK. Rspo3 functions by inducing Sdc4-dependent, clathrin-mediated endocytosis. We show that this internalization is essential for PCP signal transduction, suggesting that endocytosis of Wnt-receptor complexes is a key mechanism by which R-spondins promote Wnt signaling.

Basic Information on RSPO3

Ligand Name: R-spondin 3

Other Symbols: THSD2, FLJ14440

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: RSPO3

GeneCards: RSPO3

HGNC Gene Group: Receptor ligands: R-spondin family

Functional Annotations for RSPO3

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for RSPO3

RSPO3 — FZD8 ・ RSPO3 — LGR4 ・ RSPO3 — LGR5 ・ RSPO3 — LGR6 ・ RSPO3 — LRP6

Basic Information on SDC4

Receptor Name: syndecan 4

Other Symbols: SYND4, amphiglycan, ryudocan

Receptor Location: cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: SDC4

GeneCards: SDC4

HGNC Gene Group: Proteoglycans

Functional Annotations for SDC4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for SDC4

ADAM12 — SDC4 ・ CCL5 — SDC4 ・ CXCL10 — SDC4 ・ FGF2 — SDC4 ・ MDK — SDC4 ・ TFPI — SDC4 ・ TGM2 — SDC4 ・ THBS1 — SDC4 ・ CCN1 — SDC4 ・ ANGPTL4 — SDC4 ・ FN1 — SDC4 ・ LAMA3 — SDC4 ・ PTN — SDC4 ・ THY1 — SDC4