CDB25:0004179 RGMA — TFR2

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation.

Journal of hepatology, 2012; PubMed, Homo sapiens RGMA — Homo sapiens TFR2

ABSTRACT: The hereditary hemochromatosis-associated membrane proteins HFE, TfR2, and HJV are required for adequate hepatic expression of the iron hormone hepcidin. While the genetic interactions are clear, it remains elusive how bone morphogenetic protein co-receptor HJV functions together with HFE and TfR2 to activate hepcidin transcription via the BMP-SMAD signaling pathway. Here, we investigate whether HFE, TfR2, and HJV physically interact on the surface of hepatocytes.

Basic Information on RGMA

Ligand Name: repulsive guidance molecule BMP co-receptor a

Other Symbols: RGM

Ligand Location: secreted based on hpa, cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: RGMA

GeneCards: RGMA

HGNC Gene Group: Repulsive guidance molecule family

Functional Annotations for RGMA

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for RGMA

RGMA — NEO1

Basic Information on TFR2

Receptor Name: transferrin receptor 2

Other Symbols: HFE3, TFRC2

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: TFR2

GeneCards: TFR2

HGNC Gene Group: M28 metallopeptidases

Functional Annotations for TFR2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for TFR2

TF — TFR2