CDB25:0004133 PRTN3 — CD177

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Interaction between CD177 and platelet endothelial cell adhesion molecule-1 downregulates membrane-bound proteinase-3 (PR3) expression on neutrophils and attenuates neutrophil activation induced by PR3-ANCA.

Arthritis research & therapy, 2018; PubMed, Homo sapiens PRTN3 — Homo sapiens CD177

ABSTRACT: A recent study found that CD177 served as a receptor of membrane-bound proteinase-3 (mPR3) in a subset of neutrophils. Furthermore, CD177 has been identified as a high-affinity heterophilic binding partner for the endothelial cell platelet endothelial cell adhesion molecule-1 (PECAM-1). The current study aimed to investigate whether the interaction between PECAM-1 and CD177 could influence mPR3 expression as well as PR3-antineutrophil cytoplasmic antibody (ANCA)-induced neutrophil activation and glomerular endothelial cell (GEnC) injury.

Basic Information on PRTN3

Ligand Name: proteinase 3

Other Symbols: PR-3, ACPA, C-ANCA, AGP7, MBT, P29

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on uniprot

HGNC Gene Symbol Report: PRTN3

GeneCards: PRTN3

HGNC Gene Group: Granule associated serine proteases of immune defence

Functional Annotations for PRTN3

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for PRTN3

Basic Information on CD177

Receptor Name: CD177 molecule

Other Symbols: PRV1, HNA2A, NB1

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: CD177

GeneCards: CD177

HGNC Gene Group: LY6/PLAUR domain containing, CD molecules

Functional Annotations for CD177

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CD177

PDPN — CD177 ・ PECAM1 — CD177