CDB25:0004094 PILRA — CD8A

Experimentally validated in Human; Orthology-inferred in Rat, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset

Title

Journal:; Year Published:

Abstract

The CD8α-PILRα interaction maintains CD8+ T cell quiescence.

Science, 2022; PubMed, Homo sapiens PILRA — Homo sapiens CD8A

ABSTRACT: T cell quiescence is essential for maintaining a broad repertoire against a large pool of diverse antigens from microbes and tumors, but the underlying molecular mechanisms remain largely unknown. We show here that CD8α is critical for the maintenance of CD8+ T cells in a physiologically quiescent state in peripheral lymphoid organs. Upon inducible deletion of CD8α, both naïve and memory CD8+ T cells spontaneously acquired activation phenotypes and subsequently died without exposure to specific antigens. PILRα was identified as a ligand for CD8α in both mice and humans, and disruption of this interaction was able to break CD8+ T cell quiescence. Thus, peripheral T cell pool size is actively maintained by the CD8α-PILRα interaction in the absence of antigen exposure.

Basic Information on PILRA

Ligand Name: paired immunoglobin like type 2 receptor alpha

Other Symbols: FDF03

Ligand Location: secreted based on uniprot, cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: PILRA

GeneCards: PILRA

HGNC Gene Group: Immunoglobulin superfamily domain containing

Functional Annotations for PILRA

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for PILRA

Basic Information on CD8A

Receptor Name: CD8 subunit alpha

Other Symbols: CD8, p32, CD8alpha

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: CD8A

GeneCards: CD8A

HGNC Gene Group: CD molecules, Immunoglobulin superfamily domain containing

Functional Annotations for CD8A

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CD8A

CEACAM5 — CD8A ・ HLA-A — CD8A ・ HLA-B — CD8A ・ HLA-C — CD8A ・ HLA-E — CD8A ・ HLA-G — CD8A