CDB25:0004079 PDCD1 — CD274

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

The programmed death ligand 1 interactome demonstrates bidirectional signaling coordinating immune suppression and cancer progression in head and neck squamous cell carcinoma.

Journal of the National Cancer Institute, 2023; PubMed, Homo sapiens PDCD1 — Homo sapiens CD274

ABSTRACT: The programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) are validated cancer targets; however, emerging mechanisms and impact of PD-L1 intracellular signaling on cancer behavior are poorly understood.

Basic Information on PDCD1

Ligand Name: programmed cell death 1

Other Symbols: SLEB2, CD279, PD1, hSLE1, PD-1

Ligand Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: PDCD1

GeneCards: PDCD1

HGNC Gene Group: CD molecules, Immunoglobulin superfamily domain containing

Functional Annotations for PDCD1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for PDCD1

PDCD1 — PDCD1LG2

Basic Information on CD274

Receptor Name: CD274 molecule

Other Symbols: PDCD1LG1, B7-H, B7H1, PD-L1, PDL1, B7-H1

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: CD274

GeneCards: CD274

HGNC Gene Group: B7 family, CD molecules, Receptor ligands, Immunoglobulin superfamily domain containing

Functional Annotations for CD274

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CD274

CD80 — CD274