CDB20:0002862 PCNA — NCR2

Experimentally validated in Human; Orthology-inferred in Rat, Frog, Chicken, Macaque, Pig, Dog, Chimp, Horse, Marmoset

Title

Journal:; Year Published:

Abstract

Proliferating cell nuclear antigen is a novel inhibitory ligand for the natural cytotoxicity receptor NKp44.

Journal of immunology, 2011; PubMed, Homo sapiens PCNA — Homo sapiens NCR2

ABSTRACT: NK cells play an important role in the early immune response to cancer. The NKp44 activating receptor is the only natural cytotoxicity receptor that is expressed exclusively by primate NK cells, yet its cellular ligands remain largely unknown. Proliferating cell nuclear Ag (PCNA) is overexpressed in cancer cells. In this study, we show that the NKp44 receptor recognizes PCNA. Their interaction inhibits NK cell function through NKp44/ITIM. The physical interaction of NKp44 and PCNA is enabled by recruitment of target cell PCNA to the NK immunological synapse. We demonstrate that PCNA promotes cancer survival by immune evasion through inhibition of NKp44-mediated NK cell attack.

Basic Information on PCNA

Ligand Name: proliferating cell nuclear antigen

Other Symbols: N/A

Ligand Location: non-classical cell membrane based on PMID: 22021614

HGNC Gene Symbol Report: PCNA

GeneCards: PCNA

HGNC Gene Group: unknown

Functional Annotations for PCNA

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for PCNA

Basic Information on NCR2

Receptor Name: natural cytotoxicity triggering receptor 2

Other Symbols: LY95, NK-p44, CD336

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: NCR2

GeneCards: NCR2

HGNC Gene Group: CD molecules, Immunoglobulin superfamily domain containing

Functional Annotations for NCR2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for NCR2

KMT2E — NCR2 ・ NID1 — NCR2