CDB25:0004044 PCDHB11 — PCDHB11

Experimentally validated in Human; Orthology-inferred in Frog, Zebrafish, Chicken, Macaque, Chimp

Title

Journal:; Year Published:

Abstract

Functional test of PCDHB11, the most human-specific neuronal surface protein.

BMC evolutionary biology, 2016; PubMed, Homo sapiens PCDHB11 — Homo sapiens PCDHB11

ABSTRACT: Brain-expressed proteins that have undergone functional change during human evolution may contribute to human cognitive capacities, and may also leave us vulnerable to specifically human diseases, such as schizophrenia, autism or Alzheimer's disease. In order to search systematically for those proteins that have changed the most during human evolution and that might contribute to brain function and pathology, all proteins with orthologs in chimpanzee, orangutan and rhesus macaque and annotated as being expressed on the surface of cells in the human central nervous system were ordered by the number of human-specific amino acid differences that are fixed in modern populations.

Basic Information on PCDHB11

Ligand Name: protocadherin beta 11

Other Symbols: PCDH-BETA11, ME2

Ligand Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: PCDHB11

GeneCards: PCDHB11

HGNC Gene Group: Cadherins

Functional Annotations for PCDHB11

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for PCDHB11