CDB25:0003984 NID2 — LGR4

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification.

Circulation research, 2022; PubMed, Homo sapiens NID2 — Homo sapiens LGR4

ABSTRACT: Vascular calcification is closely related to the all-cause mortality of cardiovascular events. Basement membrane protein nidogen-2 is a key component of the vascular extracellular matrix microenvironment and we recently found it is pivotal for the maintenance of contractile phenotype in vascular smooth muscle cells (VSMCs). However, whether nidogen-2 is involved in VSMCs osteochondrogenic transition and vascular calcification remains unclear.

Basic Information on NID2

Ligand Name: nidogen 2

Other Symbols: N/A

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on hpa

HGNC Gene Symbol Report: NID2

GeneCards: NID2

HGNC Gene Group: unknown

Functional Annotations for NID2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for NID2

NID2 — COL13A1

Basic Information on LGR4

Receptor Name: leucine rich repeat containing G protein-coupled receptor 4

Other Symbols: GPR48

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: LGR4

GeneCards: LGR4

HGNC Gene Group: 7TM proteins

Functional Annotations for LGR4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for LGR4

NDP — LGR4 ・ RSPO1 — LGR4 ・ RSPO2 — LGR4 ・ RSPO3 — LGR4 ・ RSPO4 — LGR4 ・ TNFSF11 — LGR4