CDB25:0003953 MMP14 — FLT1

Experimentally validated in Human, Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep, Mouse

Title

Journal:; Year Published:

Abstract

MMP14 Cleavage of VEGFR1 in the Cornea Leads to a VEGF-Trap Antiangiogenic Effect.

Investigative ophthalmology & visual science, 2015; PubMed, Mus Musculus Mmp14 — Mus Musculus Flt1

ABSTRACT: To determine the possible antiangiogenic effect of metalloproteinase (MMP) 14 cleavage of vascular endothelial growth factor receptor 1 (VEGFR1) in the cornea.

Proangiogenic Interactions of Vascular Endothelial MMP14 With VEGF Receptor 1 in VEGFA-Mediated Corneal Angiogenesis.

Investigative ophthalmology & visual science, 2016; PubMed, Homo sapiens MMP14 — Homo sapiens FLT1

ABSTRACT: Matrix metalloproteinase 14 (MMP14) has been shown to be required for corneal angiogenesis. We hypothesized that the proangiogenic activity of MMP14 may be based on its selective binding to, and cleaving of, vascular endothelial growth factor receptor 1 (VEGFR1), but not VEGFR2 or VEGFR3.

Basic Information on MMP14

Ligand Name: matrix metallopeptidase 14

Other Symbols: MT1-MMP

Ligand Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: MMP14

GeneCards: MMP14

HGNC Gene Group: Metallopeptidases

Functional Annotations for MMP14

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for MMP14

Basic Information on FLT1

Receptor Name: fms related receptor tyrosine kinase 1

Other Symbols: FLT, VEGFR1

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: FLT1

GeneCards: FLT1

HGNC Gene Group: Receptor kinases, Immunoglobulin superfamily domain containing

Functional Annotations for FLT1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for FLT1

PGF — FLT1 ・ VEGFA — FLT1 ・ VEGFB — FLT1