CDB25:0003869 LEFTY1 — ACVR2A

Experimentally validated in Mixed species, Mouse; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion.

Genes to cells : devoted to molecular & cellular mechanisms, 2002; PubMed, Mus Musculus Lefty1 — Mus Musculus Acvr2a
ABSTRACT: Two TGFbeta-related proteins, Nodal and Lefty, are implicated in early embryonic patterning of vertebrates. Genetic data suggest that Nodal is a signalling molecule, while Lefty is an antagonist of Nodal, but their precise function remains unknown.
Basic Information on LEFTY1
Ligand Name: left-right determination factor 1
Other Symbols: LEFTB, LEFTYB
Ligand Location: secreted based on perplexity, uniprot
HGNC Gene Symbol Report: LEFTY1
GeneCards: LEFTY1
Functional Annotations for LEFTY1
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for LEFTY1
LEFTY1 — ACVR2B
Basic Information on ACVR2A
Receptor Name: activin A receptor type 2A
Other Symbols: ACVR2, ACTRII
Receptor Location: cell membrane based on perplexity, uniprot
HGNC Gene Symbol Report: ACVR2A
GeneCards: ACVR2A
HGNC Gene Group: Receptor kinases
Functional Annotations for ACVR2A
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for ACVR2A
BMP10 — ACVR2A ・ BMP15 — ACVR2A ・ BMP2 — ACVR2A ・ BMP3 — ACVR2A ・ BMP4 — ACVR2A ・ BMP6 — ACVR2A ・ BMP7 — ACVR2A ・ GDF11 — ACVR2A ・ GDF2 — ACVR2A ・ GDF5 — ACVR2A ・ GDF7 — ACVR2A ・ INHA — ACVR2A ・ INHBA — ACVR2A ・ INHBB — ACVR2A ・ INHBC — ACVR2A ・ INHBE — ACVR2A ・ NODAL — ACVR2A ・ CRIPTO — ACVR2A ・ BMP8A — ACVR2A ・ GDF1 — ACVR2A ・ GDF10 — ACVR2A ・ GDF3 — ACVR2A ・ GDF6 — ACVR2A ・ LEFTY2 — ACVR2A ・ MSTN — ACVR2A
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