CDB25:0003793 IL33 — IL1RAP

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts.

Gut, 2010; PubMed, Homo sapiens IL33 — Homo sapiens IL1RAP

ABSTRACT: Interleukin 33 (IL33) is a cytokine belonging to the IL1 family and it binds to a complex of the ST2L/IL1 receptor accessory protein (IL1RAcP). To define the role of IL33 in fibrogenesis of the pancreas, the expression of IL33, ST2L and IL1RAcP was examined in chronic pancreatitis tissues. The effects of IL33 on the functions of human pancreatic myofibroblasts were also investigated.

Basic Information on IL33

Ligand Name: interleukin 33

Other Symbols: C9orf26, DVS27, DKFZp586H0523, NF-HEV, IL1F11

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: IL33

GeneCards: IL33

HGNC Gene Group: Receptor ligands: Interleukins

Functional Annotations for IL33

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for IL33

IL33 — IL1RL1

Basic Information on IL1RAP

Receptor Name: interleukin 1 receptor accessory protein

Other Symbols: IL-1RAcP, IL1R3, C3orf13

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: IL1RAP

GeneCards: IL1RAP

HGNC Gene Group: TIR domain containing, Immunoglobulin superfamily domain containing, Interleukin receptors

Functional Annotations for IL1RAP

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for IL1RAP

IL1A — IL1RAP ・ IL1B — IL1RAP ・ IL36A — IL1RAP ・ IL36B — IL1RAP ・ IL36G — IL1RAP ・ PTPRD — IL1RAP