CDB15:0000901 IL26 — IL20RA

Experimentally validated in Human; Orthology-inferred in Frog, Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2.

Journal of immunology, 2004; PubMed, Homo sapiens IL26 — Homo sapiens IL20RA

ABSTRACT: The receptor for IL-26 (AK155), a cytokine of the IL-10 family, has not previously been defined. We demonstrate that the active receptor complex for IL-26 is a heterodimer composed of two receptor proteins: IL-20R1 and IL-10R2. Signaling through the IL-26R results in activation of STAT1 and STAT3 which can be blocked by neutralizing Abs against IL-20R1 or IL-10R2. IL-10R2 is broadly expressed on a wide variety of tissues, whereas only a limited number of tissues express IL-20R1. Therefore, the ability to respond to IL-26 is restricted by the expression of IL-20R1. IL-10, IL-19, IL-20, IL-22, and IL-24 fail to signal through the combination of IL-10R2 and IL-20R1 proteins, demonstrating that this receptor combination is unique and specific for IL-26.

Basic Information on IL26

Ligand Name: interleukin 26

Other Symbols: AK155, IL-26

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: IL26

GeneCards: IL26

HGNC Gene Group: Receptor ligands: Interleukins

Functional Annotations for IL26

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for IL26

IL26 — IL10RB

Basic Information on IL20RA

Receptor Name: interleukin 20 receptor subunit alpha

Other Symbols: ZCYTOR7, IL-20R1

Receptor Location: cell membrane based on perplexity

HGNC Gene Symbol Report: IL20RA

GeneCards: IL20RA

HGNC Gene Group: Interleukin receptors

Functional Annotations for IL20RA

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for IL20RA

IL19 — IL20RA ・ IL20 — IL20RA ・ IL24 — IL20RA