CDB15:0000833 IFNL1 — IL10RB

Experimentally validated in Human; Orthology-inferred in Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

IL-28, IL-29 and their class II cytokine receptor IL-28R.

Nature immunology, 2003; PubMed, Homo sapiens IFNL1 — Homo sapiens IL10RB

ABSTRACT: Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection.

Basic Information on IFNL1

Ligand Name: interferon lambda 1

Other Symbols: IL29, IL-29

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: IFNL1

GeneCards: IFNL1

HGNC Gene Group: Receptor ligands: Interferons

Functional Annotations for IFNL1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for IFNL1

IFNL1 — IFNLR1

Basic Information on IL10RB

Receptor Name: interleukin 10 receptor subunit beta

Other Symbols: CRFB4, D21S58, D21S66, CRF2-4, CDW210B, IL-10R2

Receptor Location: cell membrane based on perplexity

HGNC Gene Symbol Report: IL10RB

GeneCards: IL10RB

HGNC Gene Group: CD molecules, Interleukin receptors

Functional Annotations for IL10RB

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for IL10RB

IFNL2 — IL10RB ・ IFNL3 — IL10RB ・ IL10 — IL10RB ・ IL22 — IL10RB ・ IFNL4 — IL10RB ・ IL24 — IL10RB ・ IL26 — IL10RB