CDB15:0000792 ICAM3 — ITGAD

Experimentally validated in Human; Orthology-inferred in Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse

Title

Journal:; Year Published:

Abstract

A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3.

Immunity, 1995; PubMed, Homo sapiens ICAM3 — Homo sapiens ITGAD
ABSTRACT: The leukocyte-restricted beta 2 (CD18) integrins mediate cell adhesion in a variety of events essential for normal immune function. Despite extensive research in this field, only three members of this integrin subfamily have been described: CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1), and CD11c/CD18 (p150,95). We have identified a cDNA encoding a fourth alpha chain, alpha d, that associates with CD18. The alpha d subunit is more closely related to CD11b and CD11c than to CD11a. This integrin is expressed at moderate levels on myelomonocytic cell lines and subsets of peripheral blood leukocytes, and more strongly on tissue-compartmentalized cells such as foam cells, specialized macrophages found in aortic fatty streaks that may develop into atherosclerotic lesions. The alpha d/CD18 molecule exhibits preferential recognition of ICAM-3 over ICAM-1.
Basic Information on ICAM3
Ligand Name: intercellular adhesion molecule 3
Other Symbols: CDW50, ICAM-R, CD50
Ligand Location: cell membrane based on perplexity
HGNC Gene Symbol Report: ICAM3
GeneCards: ICAM3
Functional Annotations for ICAM3
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for ICAM3
ICAM3 — CLEC4M ・ ICAM3 — ITGAL ・ ICAM3 — ITGB2 ・ ICAM3 — CD209
Basic Information on ITGAD
Receptor Name: integrin subunit alpha D
Other Symbols: CD11d, ADB2
Receptor Location: cell membrane based on perplexity
HGNC Gene Symbol Report: ITGAD
GeneCards: ITGAD
HGNC Gene Group: CD molecules, Integrins
Functional Annotations for ITGAD
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for ITGAD
VCAM1 — ITGAD
← CDB15 ICAM3 CLEC4M
CDB15 ICAM3 ITGAL →