CDB25:0003752 ICAM2 — CD209

Experimentally validated in Human; Orthology-inferred in Rat, Frog, Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset

Title

Journal:; Year Published:

Abstract

DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking.

Nature immunology, 2000; PubMed, Homo sapiens ICAM2 — Homo sapiens CD209

ABSTRACT: Dendritic cells (DCs) are recruited from blood into tissues to patrol for foreign antigens. After antigen uptake and processing, DCs migrate to the secondary lymphoid organs to initiate immune responses. We now show that DC-SIGN, a DC-specific C-type lectin, supports tethering and rolling of DC-SIGN-positive cells on the vascular ligand ICAM-2 under shear flow, a prerequisite for emigration from blood. The DC-SIGN-ICAM-2 interaction regulates chemokine-induced transmigration of DCs across both resting and activated endothelium. Thus, DC-SIGN is central to the unusual trafficking capacity of DCs, further supported by the expression of DC-SIGN on precursors in blood and on immature and mature DCs in both peripheral and lymphoid tissues.

Basic Information on ICAM2

Ligand Name: intercellular adhesion molecule 2

Other Symbols: CD102

Ligand Location: cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: ICAM2

GeneCards: ICAM2

HGNC Gene Group: Ig-like cell adhesion molecule family, CD molecules, Receptor ligands, Immunoglobulin superfamily domain containing

Functional Annotations for ICAM2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for ICAM2

ICAM2 — ITGAL ・ ICAM2 — ITGAM ・ ICAM2 — ITGB2

Basic Information on CD209

Receptor Name: CD209 molecule

Other Symbols: DC-SIGN, hDC-SIGN, CDSIGN, DC-SIGN1, CLEC4L

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: CD209

GeneCards: CD209

HGNC Gene Group: Scavenger receptors, C-type lectin domain containing, CD molecules

Functional Annotations for CD209

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CD209

CEACAM1 — CD209 ・ ICAM3 — CD209 ・ ITGAM — CD209 ・ ITGB2 — CD209