CDB15:0000750 HLA-B — KIR2DL3

Experimentally validated in Human; Orthology-inferred in Macaque, Pig

Title

Journal:; Year Published:

Abstract

The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands.

Cell reports, 2017; PubMed, Homo sapiens HLA-B — Homo sapiens KIR2DL3
ABSTRACT: HLA-B∗46:01 was formed by an intergenic mini-conversion, between HLA-B∗15:01 and HLA-C∗01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-conversion was introduction of the C1 epitope into HLA-B∗46:01, making it an exceptional HLA-B allotype that is recognized by the C1-specific natural killer (NK) cell receptor KIR2DL3. High-resolution mass spectrometry showed that HLA-B∗46:01 has a low-diversity peptidome that is distinct from those of its parents. A minority (21%) of HLA-B∗46:01 peptides, with common C-terminal characteristics, form ligands for KIR2DL3. The HLA-B∗46:01 peptidome is predicted to be enriched for peptide antigens derived from Mycobacterium leprae. Overall, the results indicate that the distinctive peptidome and functions of HLA-B∗46:01 provide carriers with resistance to leprosy, which drove its rapid rise in frequency in Southeast Asia.
Basic Information on HLA-B
Ligand Name: major histocompatibility complex, class I, B
Other Symbols: AS
Ligand Location: cell membrane based on perplexity, uniprot
HGNC Gene Symbol Report: HLA-B
GeneCards: HLA-B
Functional Annotations for HLA-B
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for HLA-B
HLA-B — KIR3DL1 ・ HLA-B — KLRD1 ・ HLA-B — LILRB1 ・ HLA-B — LILRB2 ・ HLA-B — KIR3DL2 ・ HLA-B — CD8A ・ HLA-B — KIR3DS1
Basic Information on KIR2DL3
Receptor Name: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3
Other Symbols: cl-6, nkat2, nkat2a, nkat2b, p58, CD158B2
Receptor Location: cell membrane based on perplexity, uniprot
HGNC Gene Symbol Report: KIR2DL3
GeneCards: KIR2DL3
Functional Annotations for KIR2DL3
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for KIR2DL3
HLA-C — KIR2DL3
← CDB15 HLA-A LILRB2
CDB15 HLA-B KIR3DL1 →