CDB15:0000747 HLA-A — KIR3DL2

Experimentally validated in Human; Orthology-inferred in Frog, Macaque, Pig, Chimp, Horse

Title

Journal:; Year Published:

Abstract

A human killer inhibitory receptor specific for HLA-A1,2.

Journal of immunology, 1996; PubMed, Homo sapiens HLA-A — Homo sapiens KIR3DL2

ABSTRACT: Killer inhibitory receptors (KIRs) are transmembrane glycoproteins, expressed on NK cells and a small subset of T cells, that inhibit cell-mediated cytotoxicity upon binding to polymorphic MHC class I determinants on target cells. Although human KIRs specific for HLA-C and HLA-B molecules have been characterized, none have been shown to interact with HLA-A. Here we demonstrate that a member of the KIR cDNA family, designated NKAT4, encodes a 70-kDa receptor specific for HLA-A3.

Basic Information on HLA-A

Ligand Name: major histocompatibility complex, class I, A

Other Symbols: N/A

Ligand Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: HLA-A

GeneCards: HLA-A

HGNC Gene Group: Histocompatibility complex, Immunoglobulin superfamily domain containing

Functional Annotations for HLA-A

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for HLA-A

HLA-A — KIR3DL1 ・ HLA-A — LILRB1 ・ HLA-A — LILRB2 ・ HLA-A — CD8A ・ HLA-A — KIR2DS2 ・ HLA-A — KIR2DS4

Basic Information on KIR3DL2

Receptor Name: killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2

Other Symbols: cl-5, nkat4, nkat4a, nkat4b, CD158K

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: KIR3DL2

GeneCards: KIR3DL2

HGNC Gene Group: CD molecules, Immunoglobulin superfamily domain containing

Functional Annotations for KIR3DL2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for KIR3DL2

HLA-B — KIR3DL2 ・ HLA-F — KIR3DL2 ・ IGSF8 — KIR3DL2 ・ TAFA2 — KIR3DL2