CDB20:0002768 HHLA2 — TMIGD2

Experimentally validated in Human; Orthology-inferred in Frog, Zebrafish, Macaque, Pig, Cow, Chimp, Horse

Title

Journal:; Year Published:

Abstract

Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2015; PubMed, Homo sapiens HHLA2 — Homo sapiens TMIGD2

ABSTRACT: HHLA2 (B7H7/B7-H5/B7y) is a newly identified B7 family member that regulates human T-cell functions. However, its protein expression in human organs and significance in human diseases are unknown. The objective of this study was to analyze HHLA2 protein expression in normal human tissues and cancers, as well as its prognostic significance, to explore mechanisms regulating HHLA2 expression, and to identify candidate HHLA2 receptors.

Basic Information on HHLA2

Ligand Name: HHLA2 member of B7 family

Other Symbols: B7H7, B7-H5, B7y, B7-H7

Ligand Location: cell membrane based on perplexity

HGNC Gene Symbol Report: HHLA2

GeneCards: HHLA2

HGNC Gene Group: B7 family, Immunoglobulin superfamily domain containing

Functional Annotations for HHLA2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for HHLA2

HHLA2 — KIR3DL3

Basic Information on TMIGD2

Receptor Name: transmembrane and immunoglobulin domain containing 2

Other Symbols: MGC23244, CD28H, IGPR-1

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: TMIGD2

GeneCards: TMIGD2

HGNC Gene Group: Immunoglobulin superfamily domain containing

Functional Annotations for TMIGD2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for TMIGD2