CDB15:0000718 GHRL — GPR39

Experimentally validated in Human, Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake.

Science, 2005; PubMed, Homo sapiens GHRL — Homo sapiens GPR39

ABSTRACT: Ghrelin, a circulating appetite-inducing hormone, is derived from a prohormone by posttranslational processing. On the basis of the bioinformatic prediction that another peptide also derived from proghrelin exists, we isolated a hormone from rat stomach and named it obestatin-a contraction of obese, from the Latin "obedere," meaning to devour, and "statin," denoting suppression. Contrary to the appetite-stimulating effects of ghrelin, treatment of rats with obestatin suppressed food intake, inhibited jejunal contraction, and decreased body-weight gain. Obestatin bound to the orphan G protein-coupled receptor GPR39. Thus, two peptide hormones with opposing action in weight regulation are derived from the same ghrelin gene. After differential modification, these hormones activate distinct receptors.

Basic Information on GHRL

Ligand Name: ghrelin and obestatin prepropeptide

Other Symbols: MTLRP, ghrelin, obestatin

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: GHRL

GeneCards: GHRL

HGNC Gene Group: Receptor ligands: Neuropeptides

Functional Annotations for GHRL

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for GHRL

GHRL — GHSR

Basic Information on GPR39

Receptor Name: G protein-coupled receptor 39

Other Symbols: ZnR

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: GPR39

GeneCards: GPR39

HGNC Gene Group: 7TM proteins

Functional Annotations for GPR39

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for GPR39

GPNMB — GPR39