CDB20:0002760 FZD8 — CKAP4

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Antiproliferative factor (APF) binds specifically to sites within the cytoskeleton-associated protein 4 (CKAP4) extracellular domain.

BMC biochemistry, 2017; PubMed, Homo sapiens FZD8 — Homo sapiens CKAP4

ABSTRACT: Antiproliferative factor (APF) is a sialoglycopeptide elevated in the urine of patients with interstitial cystitis-a chronic, painful bladder disease. APF inhibits the proliferation of normal bladder epithelial cells and cancer cells in vitro, presumably by binding to its cellular receptor, cytoskeleton associated-protein 4 (CKAP4); however, the biophysical interaction of APF with CKAP4 has not been characterized previously. In this study, we used surface plasmon resonance (SPR) to explore the binding kinetics of the interaction of APF and as-APF (a desialylated APF analogue with full activity) to CKAP4.

Basic Information on FZD8

Ligand Name: frizzled class receptor 8

Other Symbols: FZ-8

Ligand Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: FZD8

GeneCards: FZD8

HGNC Gene Group: MicroRNA host genes, 7TM proteins

Functional Annotations for FZD8

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for FZD8

Basic Information on CKAP4

Receptor Name: cytoskeleton associated protein 4

Other Symbols: P63, CLIMP-63, CLIMP63, ERGIC-63

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: CKAP4

GeneCards: CKAP4

HGNC Gene Group: unknown

Functional Annotations for CKAP4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CKAP4

DKK1 — CKAP4 ・ DKK3 — CKAP4 ・ SFTPA1 — CKAP4