CDB25:0003659 FSTL1 — CD14

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4.

FEBS letters, 2012; PubMed, Homo sapiens FSTL1 — Homo sapiens CD14

ABSTRACT: Follistatin-related protein (FRP)/follistatin-like 1 (FSTL1) has multi-specific binding nature especially with TGF-β superfamily proteins, and thereby modulates organ development. However, its function in immune systems remains unclear. Previously, we reported FRP interacts with CD14, which is known to mediate toll-like receptor 4 (TLR4) signaling. Here, we investigated whether FRP activates TLR4 signaling. Recombinant FRP induced interleukin 6 or interleukin 8 production from target cells in a CD14- and TLR4-dependent manner. Moreover, similar to lipopolysaccharide (LPS), FRP induced tolerance to the second LPS stimulation. FRP has the function of evoking innate immune responses as one of the endogenous TLR4 agonists.

Basic Information on FSTL1

Ligand Name: follistatin like 1

Other Symbols: FRP, FSL1, OCC1, OCC-1, tsc36

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: FSTL1

GeneCards: FSTL1

HGNC Gene Group: MicroRNA host genes, EF-hand domain containing

Functional Annotations for FSTL1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for FSTL1

FSTL1 — DIP2A ・ FSTL1 — FZD4

Basic Information on CD14

Receptor Name: CD14 molecule

Other Symbols: N/A

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: CD14

GeneCards: CD14

HGNC Gene Group: Scavenger receptors, CD molecules

Functional Annotations for CD14

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CD14

S100A9 — CD14