CDB25:0003643 FLRT2 — FLRT2

Experimentally validated in Frog; Orthology-inferred in Human, Mouse, Rat, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Sheep

Title

Journal:; Year Published:

Abstract

A role for fibronectin-leucine-rich transmembrane cell-surface proteins in homotypic cell adhesion.

EMBO reports, 2006; PubMed, Xenopus tropicalis flrt2 — Xenopus tropicalis flrt2
ABSTRACT: The fibronectin-leucine-rich transmembrane (FLRT) family of leucine-rich repeat (LRR) proteins is implicated in fibroblast growth factor (FGF) signalling, early embryonic development and neurite outgrowth. Here, we have analysed whether FLRTs may also function in cell adhesion. We find that FLRT proteins can physically interact and that FLRT-transfected cultured cells sort out from non-transfected cells, suggesting a change in adhesive properties. A similar sorting effect is also observed in Xenopus embryos and tissue aggregates. FLRT-mediated cell sorting is calcium dependent and substrate independent. Deletion analysis indicates that cell sorting requires the LRR domains, which are dispensable for FLRT-mediated FGF signalling. Conversely, sorting is independent of the cytoplasmic domain, which is essential for FLRT-induced signalling. Therefore, FLRT-mediated FGF signal transduction and homotypic cell sorting can be molecularly uncoupled. The results indicate that FLRT proteins have a dual role, promoting FGF signalling and modulating homotypic cell adhesion.
Basic Information on FLRT2
Ligand Name: fibronectin leucine rich transmembrane protein 2
Other Symbols: N/A
Ligand Location: secreted based on uniprot, cell membrane based on perplexity, uniprot
HGNC Gene Symbol Report: FLRT2
GeneCards: FLRT2
Functional Annotations for FLRT2
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for FLRT2
FLRT2 — ADGRL1 ・ FLRT2 — ADGRL2 ・ FLRT2 — ADGRL3 ・ FLRT2 — ITGB4 ・ FLRT2 — UNC5A ・ FLRT2 — UNC5B ・ FLRT2 — UNC5C ・ FLRT2 — UNC5D
Basic Information on FLRT2
Receptor Name: fibronectin leucine rich transmembrane protein 2
Other Symbols: N/A
Receptor Location: cell membrane based on perplexity, uniprot
HGNC Gene Symbol Report: FLRT2
GeneCards: FLRT2
Functional Annotations for FLRT2
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for FLRT2
FN1 — FLRT2 ・ UNC5A — FLRT2 ・ UNC5B — FLRT2 ・ UNC5C — FLRT2 ・ UNC5D — FLRT2
← CDB25 FLRT2 ADGRL3
CDB25 FLRT2 ITGB4 →