CDB25:0003626 FGF2 — TGFBR3

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma.

The Journal of clinical investigation, 2013; PubMed, Homo sapiens FGF2 — Homo sapiens TGFBR3

ABSTRACT: Growth factors and their receptors coordinate neuronal differentiation during development, yet their roles in the pediatric tumor neuroblastoma remain unclear. Comparison of mRNA from benign neuroblastic tumors and neuroblastomas revealed that expression of the type III TGF-β receptor (TGFBR3) decreases with advancing stage of neuroblastoma and this loss correlates with a poorer prognosis. Patients with MYCN oncogene amplification and low TGFBR3 expression were more likely to have an adverse outcome. In vitro, TβRIII expression was epigenetically suppressed by MYCN-mediated recruitment of histone deacetylases to regions of the TGFBR3 promoter. TβRIII bound FGF2 and exogenous FGFR1, which promoted neuronal differentiation of neuroblastoma cells. TβRIII and FGF2 cooperated to induce expression of the transcription factor inhibitor of DNA binding 1 via Erk MAPK. TβRIII-mediated neuronal differentiation suppressed cell proliferation in vitro as well as tumor growth and metastasis in vivo. These studies characterize a coreceptor function for TβRIII in FGF2-mediated neuronal differentiation, while identifying potential therapeutic targets and clinical biomarkers for neuroblastoma.

Basic Information on FGF2

Ligand Name: fibroblast growth factor 2

Other Symbols: FGFB

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: FGF2

GeneCards: FGF2

HGNC Gene Group: Fibroblast growth factor family, Receptor ligands

Functional Annotations for FGF2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for FGF2

FGF2 — CD44 ・ FGF2 — FGFR1 ・ FGF2 — FGFR2 ・ FGF2 — FGFR3 ・ FGF2 — FGFR4 ・ FGF2 — FGFRL1 ・ FGF2 — GPC4 ・ FGF2 — NRP1 ・ FGF2 — SDC1 ・ FGF2 — SDC2 ・ FGF2 — SDC3 ・ FGF2 — SDC4 ・ FGF2 — CSPG4 ・ FGF2 — ITGAV ・ FGF2 — ITGB3 ・ FGF2 — LYVE1

Basic Information on TGFBR3

Receptor Name: transforming growth factor beta receptor 3

Other Symbols: betaglycan, BGCAN

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: TGFBR3

GeneCards: TGFBR3

HGNC Gene Group: Proteoglycans

Functional Annotations for TGFBR3

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for TGFBR3

INHA — TGFBR3 ・ INHBA — TGFBR3 ・ TGFB1 — TGFBR3 ・ TGFB2 — TGFBR3 ・ TGFB3 — TGFBR3 ・ INHBB — TGFBR3