CDB20:0002736 EPO — EPHB4

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Erythropoietin Stimulates Tumor Growth via EphB4.

Cancer cell, 2015; PubMed, Homo sapiens EPO — Homo sapiens EPHB4

ABSTRACT: While recombinant human erythropoietin (rhEpo) has been widely used to treat anemia in cancer patients, concerns about its adverse effects on patient survival have emerged. A lack of correlation between expression of the canonical EpoR and rhEpo's effects on cancer cells prompted us to consider the existence of an alternative Epo receptor. Here, we identified EphB4 as an Epo receptor that triggers downstream signaling via STAT3 and promotes rhEpo-induced tumor growth and progression. In human ovarian and breast cancer samples, expression of EphB4 rather than the canonical EpoR correlated with decreased disease-specific survival in rhEpo-treated patients. These results identify EphB4 as a critical mediator of erythropoietin-induced tumor progression and further provide clinically significant dimension to the biology of erythropoietin.

Basic Information on EPO

Ligand Name: erythropoietin

Other Symbols: EP

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: EPO

GeneCards: EPO

HGNC Gene Group: Receptor ligands

Functional Annotations for EPO

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for EPO

EPO — EPOR ・ EPO — CRLF3

Basic Information on EPHB4

Receptor Name: EPH receptor B4

Other Symbols: HTK, Tyro11

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: EPHB4

GeneCards: EPHB4

HGNC Gene Group: Receptor kinases, Fibronectin type III domain containing, Sterile alpha motif domain containing

Functional Annotations for EPHB4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for EPHB4

EFNB1 — EPHB4 ・ EFNB2 — EPHB4 ・ EFNB3 — EPHB4 ・ EFNA4 — EPHB4