CDB25:0003528 EPHA10 — EFNA1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis.

Biochimica et biophysica acta, 2005; PubMed, Homo sapiens EPHA10 — Homo sapiens EFNA1

ABSTRACT: In mammals, 14 members of the Eph receptor tyrosine kinase family have been described so far. Here we present a not yet described member of this family denoted EphA10. We report the identification of three putative EphA10 isoforms: one soluble and two transmembrane isoforms. One of the latter isoforms lacked the sterile alpha motif commonly found in Eph receptors. The gene encoding EphA10 is located on chromosome 1p34 and expression studies show that EphA10 mRNA is mainly expressed in testis. Binding studies to ephrin ligands suggests that this receptor belongs to the EphA subclass of Eph receptors binding mainly to ephrin-A ligands.

Basic Information on EPHA10

Ligand Name: EPH receptor A10

Other Symbols: FLJ16103, FLJ33655

Ligand Location: secreted based on perplexity, uniprot, cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: EPHA10

GeneCards: EPHA10

HGNC Gene Group: Receptor kinases, Fibronectin type III domain containing, Sterile alpha motif domain containing

Functional Annotations for EPHA10

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for EPHA10

EPHA10 — EFNA2 ・ EPHA10 — EFNA3 ・ EPHA10 — EFNA4 ・ EPHA10 — EFNA5

Basic Information on EFNA1

Receptor Name: ephrin A1

Other Symbols: TNFAIP4, EPLG1, LERK1, ECKLG, GMAN

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: EFNA1

GeneCards: EFNA1

HGNC Gene Group: Cupredoxin superfamily, Receptor ligands: Ephrins

Functional Annotations for EFNA1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for EFNA1

EPHA1 — EFNA1 ・ EPHA2 — EFNA1 ・ EPHA3 — EFNA1 ・ EPHA4 — EFNA1 ・ EPHA5 — EFNA1 ・ EPHA6 — EFNA1 ・ EPHA7 — EFNA1 ・ EPHA8 — EFNA1 ・ EPHB2 — EFNA1