CDB15:0000429 DEFB103B — CCR2

Experimentally validated in Human; Orthology-inferred in Macaque, Pig, Dog, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Defensin DEFB103 bidirectionally regulates chemokine and cytokine responses to a pro-inflammatory stimulus.

Scientific reports, 2013; PubMed, Homo sapiens DEFB103B — Homo sapiens CCR2

ABSTRACT: Human β defensin DEFB103 acts as both a stimulant and an attenuator of chemokine and cytokine responses: a dichotomy that is not entirely understood. Our predicted results using an in silico simulation model of dendritic cells and our observed results in human myeloid dendritic cells, show that DEFB103 significantly (p < 0.05) enhanced 6 responses, attenuated 7 responses, and both enhanced/attenuated the CXCL1 and TNF responses to Porphyromonas gingivalis hemagglutinin B (HagB). In murine JAWSII dendritic cells, DEFB103 significantly attenuated, yet rarely enhanced, the Cxcl2, Il6, and Csf3 responses to HagB; and in C57/BL6 mice, DEFB103 significantly enhanced, yet rarely attenuated, the Cxcl1, Csf1, and Csf3 responses. Thus, DEFB103 influences pro-inflammatory activities with the concentration of DEFB103 and order of timing of DEFB103 exposure to dendritic cells, with respect to microbial antigen exposure to cells, being paramount in orchestrating the onset, magnitude, and composition of the chemokine and cytokine response.

Basic Information on DEFB103B

Ligand Name: defensin beta 103B

Other Symbols: N/A

Ligand Location: secreted based on perplexity

HGNC Gene Symbol Report: DEFB103B

GeneCards: DEFB103B

HGNC Gene Group: Defensins

Functional Annotations for DEFB103B

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for DEFB103B

DEFB103B — CCR6 ・ DEFB103B — MC1R

Basic Information on CCR2

Receptor Name: C-C motif chemokine receptor 2

Other Symbols: CMKBR2, CC-CKR-2, CKR2, MCP-1-R, CD192, FLJ78302

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: CCR2

GeneCards: CCR2

HGNC Gene Group: 7TM proteins, CD molecules

Functional Annotations for CCR2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CCR2

CCL11 — CCR2 ・ CCL13 — CCR2 ・ CCL16 — CCR2 ・ CCL24 — CCR2 ・ CCL26 — CCR2 ・ CCL2 — CCR2 ・ CCL7 — CCR2 ・ CCL8 — CCR2 ・ CYTL1 — CCR2 ・ DEFB106A — CCR2 ・ MSMP — CCR2 ・ DEFB103A — CCR2 ・ DEFB106B — CCR2 ・ DEFB4A — CCR2 ・ DEFB4B — CCR2