CDB15:0000374 CRP — OLR1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation.

Clinical chemistry, 2011; PubMed, Homo sapiens CRP — Homo sapiens OLR1

ABSTRACT: C-reactive protein (CRP) is purported to be a risk factor that acts independently of LDL cholesterol in predicting all-cause mortality in patients with ischemic heart disease. Lectin-like oxidized LDL receptor 1 (LOX-1) impairs endothelial function and exacerbates myocardial injury. We recently demonstrated that CRP increased vascular permeability through direct binding to LOX-1. Here we examined, using a hypertensive rat model, whether LOX-1 is involved in CRP-induced complement activation.

Basic Information on CRP

Ligand Name: C-reactive protein

Other Symbols: PTX1

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: CRP

GeneCards: CRP

HGNC Gene Group: Pentraxins

Functional Annotations for CRP

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CRP

CRP — CR1 ・ CRP — FCAR ・ CRP — FCGR1A ・ CRP — FCGR2A ・ CRP — FCGR2B ・ CRP — FCGR3A ・ CRP — FCGR3B

Basic Information on OLR1

Receptor Name: oxidized low density lipoprotein receptor 1

Other Symbols: LOX-1, SCARE1, CLEC8A

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: OLR1

GeneCards: OLR1

HGNC Gene Group: Scavenger receptors, C-type lectin domain containing

Functional Annotations for OLR1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for OLR1

APOB — OLR1